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. Author manuscript; available in PMC: 2014 Mar 28.
Published in final edited form as: Allergy Asthma Proc. 2011 Sep-Oct;32(5):359–365. doi: 10.2500/aap.2011.32.3460

Table 1.

C-027 Pharmacokinetics in mice

Dose (mg/kg) Route Cmax (ng/mL) Tmax (hr) AUC0-last (hr * ng per mL) Vss (L/kg) F* (%)
5 i.v. 1424 0.083 302 37.1# ND
1 i.p. 12.9 0.5 21.5 ND ND
10 i.p 333 0.5 363 ND ND
10 o.g. 22.7 2 134 ND 22
*

Bioavailability.

#

Represents ~63 × the total body water volume.

C-027 was administered to CD-1 mice either via i.v., i.p., or o.g. routes at various concentrations. The peak concentration (Cmax) and time of Cmax (Tmax) were token directly from the observed data. The AUC, apparent volume of distribution (Vss), and bioavailability (F) were estimated with the linear trapezoidal rule using WinNonlin software Version 4.2 (Pharsight, Mountain View, CA).

AUC = area under the curve; i.v. = intravenous; i.p. = intraperitoneal; o.g. = oral lavage.