Table S1.
Compared Kv block effect.
| Name | α-KTx | Sensitive Kv channels/IC50 | Insensitive Kv channels | Reference |
|---|---|---|---|---|
| Ts6 | 12.1 | Kv1.2/6.19 nM, Kv1.3/0.55 nM, Shaker IR/* | Kv1.1, Kv1.4, Kv1.5, Kv1.6, Kv2.1, Kv3.1, Kv4.3, Kv7.1, Kv7.2, Kv7.4, hERG, KCa | #,[14] |
| Ts7 | 4.1 | Kv1.1/*, Kv1.2/*, Kv1.3/*, Kv1.6/*, Shaker IR/* | Kv1.4, Kv1.5, Kv2.1, Kv3.1, Kv7.1, hEG | #,[24,25,26,71] |
| native sqKv/20 nM, | ||||
| cloned sqKv/10 nM | ||||
| heteromultimer Kv1.2/1.1 SSM/10 nM | ||||
| heteromultimer Kv1.2/1.4 EAM/0.7 nM | ||||
| Tc30 | 4.4 | Kv1.3/* , Shaker B/* | - | [49] |
| Css20 | 2.13 | Kv1.2/1.3 nM, Kv1.3/7.2 nM | Kv1.1, Kv1.4, Kv1.5, Kv2.1, Kv11.1 (hERG) KCa1, BKCa | [80] |
| ChTx | 1.1 | Shaker/*, Kv1.3/*, KCa | - | [81,82,83] |
| KTX | 3.1 | Kv1.1/1.1 nM–Kv1.2/25 nM–Kv1.3/0.1 nM | - | [58] |
| AgTx2 | 3.2 | Shaker/*, Kv1.1/*, Kv1.3/*, Kv1.6/* | Kv2.1 | [84] |
| Aam-KTX | 3.12 | Kv1.2/*, Kv1.3/* | Kv1.1 | [58] |
| OdK2 | 3.11 | Kv1.3/7.2 nM | Kv1.1, Kv1.2, Kv1.4, Kv1.5, Kv1.6, hERG , Shaker | [51] |
| MTX | 6.2 | Kv1.1/45 nM, Kv1.2/0.8 nM, Kv1.3/180 nM, Shaker/3.4 nM | - | [85,86] |
| HsTX1 | 6.3 | Kv1.1/7 nM, Kv1.3/12 pM, IK/625 nM | Kv1.2 | [50] |
Notes: SSM: Single Subunit Model; EAM: Energy Additivity Model; #: Present Article: *: Data not reported.