Figure 2.

Conditional deletion of Runx1 in preosteoclasts decreased bone mass and increased osteoclast activity. A, Micro-CT imaging demonstrating the 3-dimensional microstructure of femoral trabecular bones of 8-week-old Runx1^F/F and CD11b-Cre;Runx1^F/F mice. B, Femoral BV/TV, Tb.N, Tb.Th, and Tb.Sp were measured in Runx1^F/F and CD11b-Cre;Runx1^F/F mice using micro-T imaging analyses. C, cortical thickness was also measured in the femurs of Runx1^F/F and CD11b-Cre;Runx1^F/F mice. D, CTX, a bone resorption degradation product, was assayed in serum obtained from 8-week-old Runx1^F/F and CD11b-Cre;Runx1^F/F mice. Data are means ± SE. n = 5 to 8 mice per group. *, P < .05 vs Runx1^F/F mice