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Loss of Runx1 in preosteoclasts decreased bone mass and increased osteoclasts in vivo without affecting osteoblasts. Femurs of 8-week-old Runx1F/F and CD11b-Cre;Runx1F/F mice were used to measure femoral BV/TV (A), Tb.N (B), Tb.Sp (C), Tb.Th (D), osteoclast surface over bone surface (Oc.S/BS) (E), and osteoclast surface over bone surface (Oc.S/BS) (F) by static histomorphometric analyses. Data are means ± SE. n = 5 to 8 mice per group. *, P < .05 vs Runx1F/F mice
