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. 2014 Feb 19;28(4):490–498. doi: 10.1210/me.2013-1351

Figure 2.

Figure 2.

Cognitive deficit and impaired hippocampus-dependent behavior in Rev-erbα KO mice. A, Short-term spatial memory was assessed in WT and Rev-erbα KO mice using the Y-maze test. Data are expressed as the percentage of spontaneous alternation between the arms ± SEM (Student's t test: *, P < .01 vs WT; n = 17–19). B, Long-term spatial memory was assessed in WT and Rev-erbα KO mice using the SOR test. Data are expressed as the percentage of preference for the DO ± SEM (two-way ANOVA: *, P < .05 genotype × condition; n = 15–17). C, Associative memory was assessed in WT and Rev-erbα KO mice using the contextual fear-conditioning test. Data are expressed as the percentage of time freezing ± SEM during the training (preshock) and the next day during the test (24-hour recall) (two-way ANOVA: *, P < .001 genotype × condition; n = 18–22). D, The quality of the nest construction was assessed on a rating scale of 1–5. The data are expressed as the mean score ± SEM (Student's t test: *, P < .001 vs WT; n = 10–16). E, Representative pictures of the nest construction.