Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Mar 28;4:4509. doi: 10.1038/srep04509

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014, Macmillan Publishers Limited. All rights reserved

This work is licensed under a Creative Commons Attribution-NonCommercial- NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

PMC Copyright notice

(A) Whole-cell Kv1.3 (left) and Kv1.1 (right) currents measured by patch-clamp in stably transfected L929 fibroblasts before (control) and after perfusion of HsTx-1 (top panels) or of HsTX1[R14A] (bottom panels). (B) Dose-response inhibition of Kv1.3 (left) and Kv1.1 (right) currents by HsTX1 ( and dashed line) and HsTX1[R14A] () fitted to a Hill equation (N = 3 cells per concentration). (C) Effects of ShK-186 ( and grey line), HsTX1 ( and dashed line), and HsTX1[R14A] () on the proliferation of rat Ova-GFP T_EM lymphocytes (left) and of rat splenic T lymphocytes [mainly naïve/T_CM cells] (right) measured ex vivo by the incorporation of [³H] thymidine in the DNA of dividing cells (N = 3). (D) Effects of ShK-186 ( and grey line), HsTX1 ( and dashed line), and HsTX1[R14A] () on the proliferation of human NA-NK (left) and A-NK (right) lymphocytes (N = 3).

Inline graphic — (A) Whole-cell Kv1.3 (left) and Kv1.1 (right) currents measured by patch-clamp in stably transfected L929 fibroblasts before (control) and after perfusion of HsTx-1 (top panels) or of HsTX1[R14A] (bottom panels). (B) Dose-response inhibition of Kv1.3 (left) and Kv1.1 (right) currents by HsTX1 ( and dashed line) and HsTX1[R14A] () fitted to a Hill equation (N = 3 cells per concentration). (C) Effects of ShK-186 ( and grey line), HsTX1 ( and dashed line), and HsTX1[R14A] () on the proliferation of rat Ova-GFP T_EM lymphocytes (left) and of rat splenic T lymphocytes [mainly naïve/T_CM cells] (right) measured ex vivo by the incorporation of [³H] thymidine in the DNA of dividing cells (N = 3). (D) Effects of ShK-186 ( and grey line), HsTX1 ( and dashed line), and HsTX1[R14A] () on the proliferation of human NA-NK (left) and A-NK (right) lymphocytes (N = 3).