Table 1.
Baseline characteristics of study population by hemoglobin phenotype
| Characteristic | HbAA (n=4369) | Any Hb Traita (n=633) | HbAS (n=513) | HbAC (n=120) |
|---|---|---|---|---|
| Age (yr) | 59.8 (14.0) | 60.3 (14.1) | 60.7 (14.1) | 58.5 (14.0) |
| Sex | ||||
| Men | 2218 (50.8) | 314 (49.6) | 261 (50.9) | 53 (44.2) |
| Women | 2151 (49.2) | 319 (50.4) | 252 (49.1) | 67 (55.8) |
| Weight (kg)b | 78.0 (65.0, 94.5) | 78.0 (65.2, 92.0) | 78.0 (65.4, 91.1) | 78.1 (64.4, 99.5) |
| Hemoglobin (mg/dl) | 11.3 (0.7) | 11.3 (0.8) | 11.2 (0.8) | 11.3 (0.7) |
| ESA dose/treatment (units)b | 4364.1 (2237.4, 7903.4) | 4737.4 (2566.0, 8645.5) | 4701.1 (2611.9, 8489.2) | 5449.2 (2550.5, 9832.4) |
| ESA dose/kg per treatment (units)b | 55.5 (27.8, 103.0) | 60.5 (33.8, 114.3) | 60.0 (33.8, 113.4) | 61.0 (34.1, 123.2) |
| Iron dose (iv)/treatment (mg)b | 5.7 (4, 7.6) | 5.7 (3.8, 7.6) | 5.7 (3.6, 7.6) | 6.0 (4.9, 7.9) |
| Number treatments/mob | 12.6 (11.7, 13) | 12.7 (12, 13.1) | 12.7 (12, 13.1) | 12.7 (12, 13.1) |
| Number treatments totalb | 88 (79, 91) | 89 (83, 92) | 89 (83, 92) | 89 (80.5, 92) |
| Missed treatments (%)b | 0 (0, 2.5) | 0 (0, 2.2) | 0 (0, 2.2) | 0 (0, 1.9) |
| Hospital days/prescribed txsb | 0 (0, 0.07) | 0 (0, 0.07) | 0 (0, 0.06) | 0 (0, 0.09) |
| Dialysis vintage (yr)b | 3.4 (1.6, 6.3) | 3.3 (1.5, 6.1) | 3.3 (1.5, 6.1) | 3.7 (1.3, 6.3) |
| Equilibrated Kt/V | 1.46 (0.21) | 1.46 (0.18) | 1.46 (0.18) | 1.45 (0.19) |
| Albumin (mg/dl) | 3.88 (0.35) | 3.89 (0.35) | 3.89 (0.35) | 3.86 (0.36) |
| Ferritin (ng/ml)b | 1001 (712.1, 1260.6) | 1002.5 (683.8, 1285.3) | 999 (677.6, 1285.5) | 1025.9 (764.3, 1249) |
| Transferrin saturation (%) | 34.5 (8.7) | 35.0 (9.3) | 35.0 (9.3) | 34.9 (9.6) |
| iPTH (pg/ml)b | 356.4 (239.4, 565.7) | 345.6 (243.5, 528.5) | 348.3 (239.3, 540.8) | 341.8 (248.7, 516.0) |
| Vascular access | ||||
| AVF | 1846 (42.4) | 265 (41.9) | 211 (41.1) | 54 (45.0) |
| AVG | 1251 (28.7) | 191 (30.2) | 162 (31.6) | 29 (24.2) |
| Indwelling catheter | 1256 (28.9) | 177 (28.0) | 140 (27.3) | 37 (30.8) |
| Diabetes | 2245 (51.4) | 341 (53.9) | 270 (52.6) | 71 (59.2) |
Txs, treatments; iPTH, intact parathyroid hormone.
a
Includes HbAS and HbAC.
b
Median (interquartile range).