Table 1. Selected studies of accelerated proton beam therapy for early-stage non-small cell lung cancer.

Study and reference	Year	No. of patients	Regimen	Toxicity	Control and survival rates
Bush et al. (8)	2013	111	Dose escalation (50-70 Gy in 10 fractions)	No patients with grade ≥2 RP; 4 patients with rib fractures	4-year outcomes for 70 Gy: OS 51%; DSS 74%; LC 86-91% for T1 tumors, 45-74% for T2 tumors
Hata et al. (9)	2007	21	50-60 Gy in 10 fractions	1 patient with grade 2 RP; 1 patient with painful subcutaneous induration; 1 patient with chest wall myositis	2-year outcomes: OS 74%; DSS 86%; LC 95%
Iwata et al. (10)	2010	57 (23 with carbon therapy)	60 Gy in 10 fractions	13% grade ≥2 RP; 16% grade 2 dermatitis; 4% grade 3 dermatitis; 23% grade 2 rib fracture; 6% grade 2 fibrosis of soft tissue	3-year outcomes: OS 75%; DSS 86%; LC 82%
Chang et al. (11)	2011	13	87.5 Gy in 35 fractions	11% grade 2 RP; 1 patient with grade 2 esophagitis; 67% grade 2 dermatitis; 17% grade 3 dermatitis	2-year outcomes: OS 55%; DFS 46%
Westover et al. (12)	2012	15 (20 tumors)	42-50 Gy in 3-5 fractions	1 patient with grade 2 fatigue; 1 patient with grade 2 dermatitis; 3 patients with rib fracture; 1 patient with grade 3 RP	2-year outcomes: OS 64%; LC 64%

Abbreviations: RP, radiation pneumonitis; OS, overall survival; DSS, disease-specific survival; LC, local control; DFS, disease-free survival.