Table 1. Description of included trials using hyperfractionation radiotherapy schedule in non-small cell lung cancer.

Trial	No. patients randomised	Inclusion period	RT dose/no. of fractions	Dose per fraction	Duration (weeks)	Chemotherapy
RTOG 8808-ECOG 4588 (15,16)	326	1989-1992	Control arm: 60 Gy/30	2 Gy OD	6	None
			Experimental arm: 69.6 Gy/58	1.2 Gy BID	6	None
RTOG 9410 (17)	610	1994-1998	Study 1: 63 Gy/34	1.8 Gy ×25, 2.0 Gy ×9 OD	7	Sequential
			Study 2: 63 Gy/34	1.8 Gy ×25, 2.0 Gy ×9 OD	7	Concurrent
			Study 3: 69.6 Gy/58	1.2 Gy BID	6	Concurrent

Abbreviations: RT, radiotherapy; BID, RT given twice a day; ECOG, Eastern Cooperative Oncology Group; No, number; OD, RT given once a day; RTOG, Radiation Therapy Oncology Group.