Table 1. Selected studies using FDG-PET for detecting recurrence following SABR.
Study | Number of patients | Number of recurrences [proportion pathology proven %] | SUVmax cutoff | Sensitivity (%) | Specificity (%) | Definition of local recurrence if not biopsied |
---|---|---|---|---|---|---|
Essler, et al. (50) | 29 | 6 [NR] | 5.48 | NR | NR | Increase in tumor volume of more than 25% on CT, accompanied by metabolic activity in FDG-PET |
Bollineni, et al. (49) | 132 | 6 [50] | 5.0 | NR | NR | Based on growth by more than 20% of the tumor diameter compared with the pretreatment |
Zhang, et al. (47) | 128 | 9 [78] | 5.0 | 100 | 91 | PET/CT |
Takeda et al. (48) | 154 | 17 [18] | 3.2 (early) | 100 | 96-98 | Increase in the cross-sectional tumor size of >25% on successive CT scans at least three times over a 6-month period |
4.2 (late) |
NR, not reported.