Table 1.

Epidemiological studies of DNA repair gene SNPs and prostate cancer risk.

Gene	Race	Study design	Case	Control	Genotype Distribution¹	Comparisons	Adjustment²	Odds ration (95%CI)	Ref.
ADPRT V762A	Caucasian	Hospital	438	427	70,26,4 73,25,2	VA vs. VV AA vs. VV	Age, BPH, FH	1.2 (0.9–1.6) 2.7 (1.1–6..5)	[28]
	African Americans	Hospital	50	97	90,10,0 91,9,0	VA vs. VV AA vs. VV		1.0 (0.2–4.0) NA

APE1 D148E	Caucasian	Hospital	228	219	28,54,18 34,50,16	DE vs. DD EE vs. DD	Age, S, FH	1.2 (0.8–1.9) 1.2 (0.7–2.2)	[11]
	African Americans	Population	124	116	34,52,14 38,53,10	DE vs. DD EE vs. DD	Age, S	1.2 (0.7–2.2) 1.6 (0.6–3.8)
APE1 Q51H	Caucasian	Hospital	228	219	89,10, 1 85,14, 1	QH vs. QQ HH vs. QQ	Age, S, FH	0.6 (0.3–1.2) 0.6 (0.03–14)	[11]
	African Americans	Population	124	116	79,19, 2 71,26, 3	QH vs. QQ HH vs. QQ	Age, S	0.8 (0.4–1.5) 0.7 (0.1–3.1)

ATM D1853N	Caucasians	Population	637	455	73,24,3 69,28,3	ga vs. gg aa vs. gg	None	0.8 (0.7–1.1) 1.0 (0.5–2.1)	[30]
ATM D1853V	Caucasians	Population	637	455	99,1,0 99,1,0	ta vs. aa	None	0.9 (0.2–3.3)	[30]
ATM ivs38-8t>c	Caucasians	Population	637	455	93,7,0 93,7,0	ct/cc vs. tt	None	1.0 (0.6–1.6)	[30]
ATM ivs38-15g>c	Caucasians	Population	637	455	98,2,0 99,1,0	gc vs. gg	None	1.8 (0.6–5.7)	[30]
ATMP1054R	Caucasians	Population	637	455	92,7,0 96,4,0	PR/RR vs. PP	None	2.1 (1.2–3.9)	[30]

hOGG1 a10660t	Mixed (93% Caucasians)	Hospital	245	222	65,32, 4 61,32, 7	tt vs. aa	Age	NS	[16].
hOGG1 a11657g	Mixed (93% Caucasians)	Hospital	245	222	70,25, 5 74,25, 1	gg vs. aa	Age	9.8 (1.2–76.9)	[16].
	Mixed (84% Caucasians)	Family	159	222	67,29, 5 74,25, 1	gg vs. aa	Age	13.9 (1.6–125)
hOGG1 a11657g	Mixed (84% Caucasians)	Hospital	996	1092	70,27, 3 71,25, 4	ag vs. aa gg vs. aa	Age	NS	[26]
hOGG1 a11826t	Mixed (93% Caucasians)	Hospital	245	222	66,31, 3 60,33, 7	tt vs. aa	Age	NS	[16].
hOGG1 a7143g	Mixed (93% Caucasians)	Hospital	245	222	68,26, 5 71,28, 1	gg vs. aa	Age	5.1 (1.1–23.3)	[16].
	Mixed (84% Caucasians)	Family	159	222	64,32, 5 71,28, 1	gg vs. aa	Age	8.2 (1.5–45.5)
hOGG1 a9110g	Mixed (93% Caucasians)	Hospital	245	222	66,31, 3 60,34, 7	gg vs. aa	Age	NS	[16].
hOGG1 c10629g	Mixed (93% Caucasians)	Hospital	245	222	28,44,27 30,41,30	gg vs. cc	Age	NS	[16].
hOGG1 g3402a	Mixed (93% Caucasians)	Hospital	245	222	40,44,16 43,45,12	aa vs. gg	Age	NS	[16].
hOGG1 g3574a	Mixed (93% Caucasians)	Hospital	245	222	67,28, 5 60,34, 6	aa vs. gg	Age	NS	[16].
hOGG1 g6170c	Mixed (93% Caucasians)	Hospital	245	222	63,33, 4 58,34, 7	cc vs. gg	Age	NS	[16].
hOGG1 S326C	Caucasians	Hospital	84	252	58,35, 7 74,25, 1	SC vs. SS CC vs. SS	Age, S	1.8 (1.0–3.3) 7.8 (1.7–36)	[14]
hOGG1 S326C	Mixed (93% Caucasians)	Hospital	245	222	61,36, 3 55,36, 9	CC vs. SS	Age	0.3 (0.1–0.8)	[16].
	Mixed (84% Caucasians)	Family	159	222	61,35, 4 55,36, 9	CC vs. SS	Age	0.5 (0.2–1.7)
hOGG1 S326C	Mixed (84% Caucasians)	Hospital	996	1092	60,35, 5 57,35, 8	SC vs. SS CC vs. SS	Age, race, FH, DRE, PSA	0.9 (0.8–1.1) 0.7 (0.5–1.0)	[26]
hOGG1 S326C	Mixed (90% Caucasians)	Family	439	479	64,31, 5 54,30, 6	SC vs. SS CC vs. SS	Age	1.1 (0.7–1.6) 0.7 (0.3–1.7)	[18]

MGMT I143V	Chinese	Population	162	251	96, 3, 1 98, 2, 0	VV/IV vs. II	Age	1.9 (0.6–6.2)	[12]
MGMT L84F	Chinese	Population	162	251	76,22,1 86,13,1	LF vs. LL FF va. LL	Age	2.0 (1.2–3.3) 3.4 (0.3–38.1)	[12]

hHR23B A249V	Mixed (90% Caucasians)	Hospital	494	470	29³	AA vs. AV/VV	Age,BPH, FH, S	1.1 (0.8–1.4)	[17]

NBS1E185Q	unknown	Family	121	200	33,52,15 44,40,16	EQ vs. EE QQ vs. EE	none	1.4 (0.7–2.8) 0.8 (0.4–1.6)	[29]
		Population	200	200	41,47,12 44,40,16	EQ vs. EE QQ vs. EE		1.6 (0.9–2.9) 1.2 (0.7–2.3)

XPC A499V	Mixed (90% Caucasians)	Hospital	494	470	24³	AA/AV vs. VV	Age,BPH, FH, S	0.9(0.5–1.5)	[17]
XPC K939Q	Mixed (90% Caucasians)	Hospital	494	470	38³	KK/KQ vs. QQ	Age,BPH, FH, S	1.0 (0.7–1.4)	[17]
XPC K939Q	Japanese	Hospital	165	165	47,47,6 44.42.14	KK/KQ vs. QQ	Age	2.5 (1.1–5.5)	[10]

XPD c-114g	Taiwanese	Hospital	123	479	28,53,19 31,46,23	DN/NN vs. DD		1.0 (0.7–1.5)	[20]

XPD D312N	Mixed	Siblings	637	480	44,45,12 44,48, 8	NN vs. DN/DD	None	1.6 (1.0–2.5)	[13]
	Caucasian	Siblings	572	437	40,47,13 41,50, 9	NN vs. DN/DD	None	1.6 (1.0–2.5)
XPD D312N	Mixed (90% Caucasians)	Hospital	494	470	41³	NN vs. DN/DD	Age,BPH, FH, S	0.8 (0.5–1.2)	[17]
XPD D312N	Taiwanese	Hospital	123	479	50,32,18 65,22,13	DN/NN vs. DD		1.8 (1.2–2.7)	[20]
XPD K751Q	Mixed (90% Caucasians)	Hospital	494	470	35³	KQ/QQ vs. KK	Age,BPH, FH, S	0.9 (0.6–1.4)	[17]
XPD K751Q	Chinese	Population	162	251	88,12,0 86,13,1	KQ/QQ vs. KK	Age	0.8 (0.5–1.5)	[12]
XPD K751Q	Mixed	Siblings	637	480	40,47,13 41,47,12	QQ vs. KQ/KK	None	1.1 ( 0.7–1.8)	[13]
	Caucasian	Siblings	572	437	39,48,13 41,47,12	QQ vs. KQ/KK	None	1.2 (0.7–2.0)

XPD K751Q	Taiwanese	Hospital	123	479	91,7,2 92,7,1	DN/NN vs. DD		1.3 (0.6–2.5)	[20]

XPF/ERCC4 R415Q	Mixed (90% Caucasians)	Hospital	494	470	9³	RQ vs. RR	Age, BPH, S. FH	1.4 (1.0–2.0)	[17]

XPG/ERCC5 D1104H	Mixed (90% Caucasians)	Hospital	494	470	46³	DD/DH vs. HH	Age, BPH, S, FH	0.8 (0.5–1.5)	[17]

XRCC1 R194W	Mixed (90% Caucasians)	Population	76	182	88,12,0 84,15,1	RW/WW vs. RR	Age, race	0.7 (0.3–1.6)	[15]
XRCC1 R194W	Japanese	Hospital	165	165	42,48,13 52,38,10	RW/WW vs. RR	Age	1.5 (0.9–2.2)	[10]
XRCC1 R194W	Chinese	Hospital	207	235	50,41,9 39,50,11	RW/WW vs. RR	Age,S,AL FH	0.6 (1.1–2.5)	[31]
XRCC1 R280H	Mixed (90% Caucasians)	Population	76	182	87,13,0 90,10,0	RH vs. RR	Age, race	1.5 (0.7–3.6)	[15]
XRCC1 R280H	Chinese	Hospital	207	235	80,19,1 82,17,1	RR/RH vs. HH	Age,S,AL FH	1.1 (0.7–1.9)	[31]
XRCC1 R399Q	Caucasian	Hospital	228	219	42,46,12 50,40,10	RQ vs. RR QQ vs. RR	Age, S, FH	1.6 (1.1–2.5) 1.6 (0.8–3.1)	[11]
	African Americans	Population	124	116	73,24,3 73,24,3	RQ vs. RR QQ vs. RR	Age, S	1.2 (0.6–2.2) 1.5 (0.3–8.2)
XRCC1 R399Q	Chinese	Hospital	207	235	52,41,7 65,31,4	RR/RQ vs. QQ	Age,S,AL FH	1.7 (1.1–2.5)	[31]
XRCC1 R399Q	Chinese	Population	162	251	55,34,11 54,41,5	RQ vs. RR QQ vs. RR	Age	0.8 (0.5–1.3) 2.2 (1.0–4.8)	[12]
XRCC1 R399Q	Japanese	Hospital	165	165	53,38,9 52,42,6	RQ/QQ vs. RR	Age	1.0 (0.6–1.5)	[10]
XRCC1 R399Q	Mixed	Siblings	637	480	46,43,11 45,43,12	QQ vs. RQ/RR	None	0.9(0.6–1.4)	[13]
	Caucasians	Siblings	572	437	43,45,12 41,46,13	QQ vs. RQ/RR	None	0.9(0.5–1.4)
XRCC1 R399Q	Mixed (90% Caucasians)	Population	76	182	49,39,12 42,43,15	RQ vs. RR QQ vs. RR	Age, race	0.8 (0.5–1.4) 0.7 (0.3–1.6)	[15]
XRCC1 R399Q	Mixed (92% Caucasians)	Population	77	174	49, (51)⁴ 43, (57)	RQ vs. RR QQ vs. RR	none	0.8 (0.4–1.5) 0.7 (0.3–1.7)	[27]

XRCC3 T241M	Chinese	Population	162	251	87,11,2 87,13,1	TM vs. TT MM vs. TT	Age	0.8 (0.5–1.6) 2.2 (0.4–13.7)	[12]

XRCC7 g6721t	Japanese	Hospital	165	165	7,48,45 7,41,52	gt/tt vs. gg	Age	1.0 (0.5–1.2)	[10]

numbers are percentages of each genotypes, and single number indicates percentage of minor allele frequency

BPH benign prostate hyperplasia, FH: family history of prostate cancer, S, Smoking, AL, alcohol

minor allelic frequency

⁴

heteozygous and homozygous polymorphic genotypes were combined