Table 1.
Description of COGENT cohorts.
| Dataseta | Genotyping Platform |
Concordanceb | Genotypes after QC |
N | %Male | Mean Age (SD) | Lambdac |
|---|---|---|---|---|---|---|---|
| Germany | Illumina OE d | 99.50% | 1,078,289 | 594 | 51% | 54.0 (15.0) | 1.01 |
| LOGOS | Illumina OE | 99.40% | 835,287 | 802 | 100% | 22.3 (3.8) | 1.03 |
| IBG | Affymetrix 6.0 | 99.59% | 938,800 | 299 | 77% | 15.9 (1.5) | 1.00 |
| LBC1936 | Illumina 610 | 99.60% | 1,058,722 | 1005 | 51% | 69.5 (0.8) | 1.01 |
| TOP | Affymetrix 6.0 | 94.23% | 917,315 | 351 | 48% | 34.2 (9.8) | 1.01 |
| NCNG | Illumina 610 | 99.40% | 944,135 | 629 | 32% | 47.6 (18.3) | 1.00 |
| Manchester | Illumina 610 | 99.60% | 1,059,916 | 697 | 30% | 67.7 (2.8) | 1.01 |
| HBCS | Illumina 610 | 99.60% | 1,043,380 | 318 | 100% | 67.7 (2.3) | 1.00 |
| ZHH | Illumina OE | 99.40% | 1,043,785 | 201 | 47% | 39.1 (1.8) | 1.06 |
a
Detailed descriptions of each cohort provided in Supplementary Text.
b
Concordance between imputed and genotyped SNPs.
c
Lambda to refers λGC,, a measure of the degree of statistical inflation in genomewide association studies.
d
OE refers to the Illumina OmniExpress genotyping bead chip