Table 4.
Examination of cognitive associations (in COGENT meta-analysis) for SNPs identified in published GWAS for schizophrenia (excluding MHC).
| Source | SNP | Region | Gene | Risk Allele Freqa |
OR_Sza | COGENT studies |
P_COGENT meta-analysis |
|---|---|---|---|---|---|---|---|
| Ripke (PGC) Nat Gen 2011 | rs1625579 | 1p21.3 | MIR137 | 0.8 | 1.12 | 8 | 0.4789 |
| Shi (China) Nat Gen 2011 | rs10489202 | 1q24.2 | MPC2 | 0.141 | 1.23 | 9 | 0.9024 |
| Ripke (PGC) Nat Gen 2011 | rs6703335 | 1q43 | SDCCAG8 | 0.56 | 1.09 | 6 | 0.9127 |
| O’Donovan Nat Gen 2011 | rs1344706 | 2q32.1 | ZNF804A | 0.59 | 1.12 | 9 | 0.4048 |
| Ripke (PGC) Nat Gen 2011 | rs17662626 | 2q32.3 | PCGEM1 | 0.91 | 1.2 | 5 | 0.4509 |
| Bergen (Swe) Mol Psy 2012 | rs7709645 | 5q12.1 | ZSWIM6 | 0.475 | 1.11 | 9 | 0.7207 |
| Bergen (Swe) Mol Psy 2012b | rs12666575 | 7p22.3 | MAD1L1 | 0.673 | 1.12 | 8 | 0.0320 |
| Ripke (PGC) Nat Gen 2011 | rs10503253 | 8p23.2 | CSMD1 | 0.19 | 1.16 | 7 | 0.5874 |
| Shi (China) Nat Gen 2011c | rs16887244 | 8p11.23 | LSM1 | 0.683 | 1.19 | 9 | 0.0171 |
| Ripke (PGC) Nat Gen 2011b | rs7914558 | 10q24.32 | CNNM2 | 0.59 | 1.22 | 9 | 0.0368 |
| Ripke (PGC) Nat Gen 2011 | rs11191580 | 10q24.33 | NT5C2 | 0.91 | 1.2 | 9 | 0.6575 |
| Decode Nature 2009c | rs12807809 | 11q24.2 | NRGN | 0.83 | 1.15 | 8 | 0.0399 |
| Ripke (PGC) Nat Gen 2011 | rs12966547 | 18q21.2 | TCF4 | 0.58 | 1.4 | 8 | 0.7327 |
a
based on source publication
b
schizophrenia risk allele associated with lower cognitive ability
c
schizophrenia risk allele associated with higher cognitive ability