Table 3.
Summary of studies describing bowel preparation for capsule colonoscopy.
| Study [year] | Type of device | Bowel preparation regimen | Colon cleanliness | Sensitivity and specificity to detect polyps >6 mm |
||
|---|---|---|---|---|---|---|
| Sensitivity | Specificity | |||||
| Eliakim et al. [2006] | PCC1 | Day 2 | Low-fiber diet | 84.4 | 63 | 94 |
| Day 1 | 7–8 p.m.: PEG 3 liters | |||||
| Day 0 | 6–7 a.m.: PEG 1 liter | |||||
| 8–9 a.m.: tegaserod 6 mg, capsule ingestion | ||||||
| [10 a.m.: NaP 30 ml+12 a.m.–1 p.m.: tegaserod 6 mg] | ||||||
| 2 p.m.: NaP 15 ml | ||||||
| 4:30 p.m.: bisacodyl supp. 10 mg | ||||||
| Schoofs et al. [2006] | PCC1 | Day 2 | – | 88 | 76 | 64 |
| Day 1 | 6–9 p.m.: PEG 3 liters | |||||
| Day 0 | 6–7 a.m.: PEG 1 liter | |||||
| 8–9 a.m.: domperidone 20 mg, capsule ingestion | ||||||
| 10 a.m.: NaP 45 ml | ||||||
| 2 p.m.: NaP 30 ml | ||||||
| 4:30 p.m.: bisacodyl supp. 10 mg | ||||||
| Sieg et al. [2009] | PCC1 | Day 2 | – | 72 | ||
| Day 1 | 1–6 p.m.: PEG 3 liters | |||||
| Day 0 | 6–7 a.m.: PEG 0.5 liter | |||||
| 8–9 a.m.: domperidone 20 mg, capsule ingestion | ||||||
| 10 a.m. NaP 22 ml | ||||||
| 12 a.m.–1 p.m.: NaP 22 ml | ||||||
| 4:30 p.m.: bisacodyl supp. 10 mg | ||||||
| Van Gossum et al. [2009] | PCC1 | Day 2 | – | 72 | 64 | 84 |
| Day 1 | 6–9 p.m.: PEG 3 liters | |||||
| All day: clear liquid | ||||||
| Day 0 | 6–7 a.m.: PEG 1 liter | |||||
| 8–9 am: domperidone 20 mg, capsule ingestion | ||||||
| 10 a.m.: NaP 45 ml | ||||||
| 2 p.m.: NaP 22 ml | ||||||
| Eliakim et al. [2009] | PCC2 | Day 2 | – | 78 | 89 | 76 |
| Day 1 | Evening: PEG 2 liters | |||||
| Day 0 | Morning: PEG 2 liters | |||||
| 8–9 a.m.: capsule ingestion | ||||||
| 1–2 h later: NaP 45 ml | ||||||
| 2 h later: NaP 22 ml | ||||||
| 4:30 p.m.: bisacodyl supp. 10 mg | ||||||
| Spada et al. [2011c] | PCC1 | Day 2 | – | 35/53 | 63 | 87 |
| Day 1 | Evening: PEG 3 liters | |||||
| Day 0 | Morning: PEG 1 liter | |||||
| 8–9 a.m.: domperidone 20 mg, capsule ingestion | ||||||
| 10 a.m.: NaP 45 ml/0.5 liter PEG | ||||||
| 2 p.m.: NaP 22 ml/ 0.5 liter PEG | ||||||
| 4:30 p.m.: bisacodyl supp. 10 mg | ||||||
| Herrerias-Gutierrez et al. [2012] | PCC1 | Day 2 | Low-fiber diet | 65.5% | 84% | 62.5% |
| Day 1 | Clear liquids only | |||||
| 6–9 p.m.: PEG 3 liters | ||||||
| Day 0 | 7–8 a.m.: PEG 1 liter | |||||
| 8:45 a.m.: domperidone 20 mg | ||||||
| 9 a.m.: capsule ingestion | ||||||
| 11 a.m.: NaP 30 ml | ||||||
| 3 p.m.: NaP 15 ml | ||||||
| 5:30 p.m.: bisacodyl supp. 10 mg | ||||||
| 8 p.m.: conventional colonoscopy | ||||||
| Spada et al. [2011] | PCC2 | Day 2 | Bedtime: senna: 4 tablets | 81 | 84 | 64 |
| Multicentered | Day 1 | All day: clear liquid diet | ||||
| 109 | Day 0 | Evening: PEG 2 liters | ||||
| Morning: PEG 2 liters | ||||||
| 10 a.m.: capsule ingestion | ||||||
| [domperidone 20 mg if capsule delayed in stomach > 1 h] | ||||||
| Small bowel detection: NaP 30 ml | ||||||
| 3h later: NaP 25 ml | ||||||
| 2 h later: bisacodyl supp. 10 mg | ||||||
| Kakugawa et al. [2012]* (reduced volume/conventional preparation) | PCC1 | Day 2 | – | 94/86 | – | – |
| Day 1 | Low-fiber diet | |||||
| Bedtime: sennoside 24 mg | ||||||
| Day 0 | Morning: mosapride 15 mg, PEG 2 liters with dimethicone 400 mg | |||||
| [additional PEG 300 ml if needed (max 600 ml)], capsule ingestion | ||||||
| 2h later: magnesium citrate 50 g/water 900 ml | ||||||
| 4h later: magnesium citrate 50 g/water 900 ml | ||||||
| 1h later: mosapride 5 mg | ||||||
*
Reduced volume preparation has been described. Conventional preparation consists of PEG 2 liters on day 1 in addition to reduced volume preparation.
NaP, sodium phosphate; PCC, PillCam Colon; PEG, polyethylene glycol; supp., suppository.