Table 1. Structure and Solubility for the Eight Stereoisomeric T. cruzi Growth Inhibitors 1–8.
compd | configuration (C8,C9,C25) | relative configuration (C8,C9) | solubility (μM)a |
---|---|---|---|
1 | SSS | trans | 1 |
2 | RRS | trans | 1 |
3 | SSR | trans | 2 |
4 | RRR | trans | 1 |
5 | SRR | cis | 86 |
6 | RSS | cis | 93 |
7 | RSR | cis | 98 |
8 | SRS | cis | 87 |
Determined at pH 7.4 in PBS containing 1% DMSO.