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. 2014 Feb 13;57(6):2746–2754. doi: 10.1021/jm500059t

Table 1. Structure and Solubility for the Eight Stereoisomeric T. cruzi Growth Inhibitors 18.

graphic file with name jm-2014-00059t_0005.jpg

compd configuration (C8,C9,C25) relative configuration (C8,C9) solubility (μM)a
1 SSS trans 1
2 RRS trans 1
3 SSR trans 2
4 RRR trans 1
5 SRR cis 86
6 RSS cis 93
7 RSR cis 98
8 SRS cis 87
a

Determined at pH 7.4 in PBS containing 1% DMSO.