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. 2014 Mar 6;57(6):2704–2713. doi: 10.1021/jm500022q

Figure 1.

Figure 1

Activity data for two examples of the same matched series [H, F, Cl, Br]. The example on the left from Carroll et al.32 (binding to dopamine transporter) has the most preferred order [Br > Cl > F > H], while that on the right from Chavette et al.33 (inhibition of COX-2) has the least preferred order [Br > H > F > Cl].