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. 2014 Mar 6;57(6):2704–2713. doi: 10.1021/jm500022q

Figure 3.

Figure 3

(a) Decision tree described by Topliss23 for a substituted phenyl ring. The abbreviations used follow Topliss (e.g., 4-Cl means 4-chlorophenyl). Only the portion of the Topliss tree discussed in the text is shown (the dotted lines indicate further branches). (b) Matsy predictions for a substituted phenyl ring given either [H > 4-Cl] or [4-Cl > H]. The 2-naphthyl replaces the phenyl ring (rather than being a substituent).