Table 1. Preferred Activity Order for Halide Matched Series.
| series | enrichment | p (corrected)a | observations |
|---|---|---|---|
| F > H | 1.06 | 0.000 (0.000) | 8250 |
| H > F | 0.94 | 0.000 (0.000) | 7338 |
| Cl > F > H | 1.85 | 0.000 (0.000) | 1185 |
| H > F > Cl | 1.08 | 0.038 (0.189) | 690 |
| F > Cl > H | 0.88 | 0.001 (0.005) | 566 |
| Cl > H > F | 0.79 | 0.000 (0.000) | 504 |
| F > H > Cl | 0.78 | 0.000 (0.000) | 503 |
| H > Cl > F | 0.63 | 0.000 (0.000) | 401 |
| Br > Cl > F > H | 5.62 | 0.000 (0.000) | 230 |
| Cl > Br > F > H | 2.79 | 0.000 (0.000) | 114 |
| H > F > Cl > Br | 1.69 | 0.000 (0.001) | 69 |
| F > Cl > Br > H | 1.47 | 0.004 (0.090) | 60 |
| Br > Cl > H > F | 1.39 | 0.013 (0.302) | 57 |
| Cl > Br > H > F | 0.88 | 0.473 (10.873) | 36 |
| F > Cl > H > Br | 0.86 | 0.380 (8.738) | 35 |
| Cl > F > Br > H | 0.83 | 0.299 (6.880) | 34 |
| Br > H > Cl > F | 0.81 | 0.231 (5.304) | 33 |
| H > Br > Cl > F | 0.76 | 0.128 (2.954) | 31 |
| H > F > Br > Cl | 0.73 | 0.093 (2.132) | 30 |
| Br > F > Cl > H | 0.68 | 0.038 (0.865) | 28 |
| F > Br > Cl > H | 0.66 | 0.025 (0.574) | 27 |
| F > H > Cl > Br | 0.61 | 0.008 (0.191) | 25 |
| Cl > F > H > Br | 0.56 | 0.003 (0.069) | 23 |
| Cl > H > F > Br | 0.49 | 0.000 (0.009) | 20 |
| H > Br > F > Cl | 0.49 | 0.000 (0.009) | 20 |
| Cl > H > Br > F | 0.46 | 0.000 (0.004) | 19 |
| Br > F > H > Cl | 0.44 | 0.000 (0.002) | 18 |
| H > Cl > Br > F | 0.44 | 0.000 (0.002) | 18 |
| F > H > Br > Cl | 0.42 | 0.000 (0.001) | 17 |
| H > Cl > F > Br | 0.37 | 0.000 (0.000) | 15 |
| F > Br > H > Cl | 0.34 | 0.000 (0.000) | 14 |
| Br > H > F > Cl | 0.22 | 0.000 (0.000) | 9 |
a
The p-value measured the likelihood of the observed enrichment occurring by chance. This was measured using a two-tailed binomial test. The p-value was corrected for multiple testing using the Bonferroni correction. This is a conservative correction that involves multiplying the original p-value by the degrees of freedom. Here there were N! – 1 degrees of freedom, and so the values for N = 4 were corrected by multipling by 23. Values are considered to be significant if the corrected p-value is ≤0.05.