Figure 1.

A schematic diagram of the hypothesized modulatory role of 5-HT receptors on glutamatergic neurotransmission. A glutamatergic pyramidal neuron and several GABA interneurons expressing the 5-HT₃, 5-HT_1A, 5-HT₇, and 5-HT_1B receptors on either dendrites or axon terminals are shown. The multimodal compounds vortioxetine and vilazodone and their possible sites of action are also shown. Note that 5-HT_1A, 5-HT_1B, and 5-HT₇ receptors may be localized on different neuronal populations. Symbols used: VLA, vilazodone; VOR, vortioxetine.