Table 6.

Estimated Covariate Effects on Transition Intensities or Hazards Accounting for Misclassification

	Incidence or Progression (95% CI)				Regression (95% CI)			Mortality (95% CI)
	Level 1 to Level 2	Level 2 to Level 3	Level 3 to Level 4	Level 4 to Level 5	Level 2 to Level 1	Level 3 to Level 2	Level 4 to Level 3	Any AMD to Death
Baseline intensity,
relative to mortality	0.88	1.54	4.73	2.49	0.44	0.10	0.20
	(0.70–1.41)	(1.07–2.21)	(1.89–11.83)	(0.80–7.70)	(0.29–0.68)	(0.01–1.70)	(0.02–2.20)
Covariate HR
Age, per 5 years	1.58	1.51	1.29	1.25				1.67
	(1.50–1.67)	(1.39–1.64)	(1.14–1.46)	(0.99–1.57)				(1.62–1.71)
Sex, male	0.90	0.63	0.85	1.25				1.55
	(0.74–1.10)	(0.47–0.85)	(0.56–1.29)	(0.99–1.57)				(1.42–1.70)
CFH Y402H genotype
TT	1.00	1.00	1.00	1.00				1.00
CT	1.46	1.61	1.72	1.58				0.94
	(1.17–1.82)	(1.18–2.20)	(1.07–2.76)	(0.63–3.99)				(0.86–1.03)
CC	2.27	2.75	1.62	1.39				1.00
	(1.71–3.01)	(1.81–4.18)	(0.92–2.83)	(0.45–4.32)				(0.87–1.14)
AMD severity
Level 1								1.00
Level 2								1.13
								(0.93–1.36)
Level 3								0.68
								(0.35–1.30)
Level 4								1.60
								(0.94–2.75)
Level 5								1.23
								(1.01–1.50)

Level 1, no AMD; level 2, minimally severe early AMD; level 3, moderately severe early AMD; level 4, severe early AMD; level 5, late AMD. Estimates are mutually adjusted for all other covariates listed in the table. Bold text indicates results that were significant at the 5% level.