Table 3.
Log-Rank Testing of Risk Factors of Overall and Disease-Specific Survival
| Overall survival | Disease-specific survival | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Factor | Log-rank-p | Wald p | Risk ratio | Lower 95% CI | Upper 95% CI | Log-rank-p | Wald p | Risk ratio | Lower 95% CI | Upper 95% CI |
| Male sex | 0.00926 | 0.011800 | 2.729953 | 1.249367 | 5.965132 | 0.04442 | 0.050387 | 2.57665 | 0.99844 | 6.649496 |
| Age ≥45 at Level VI and VII dissection | <0.00001 | 0.000057 | 19.33731 | 4.572785 | 81.773200 | <0.00001 | 0.001731 | 25.13465 | 3.344524 | 188.890900 |
| M1 on presentation | <0.00001 | 0.000008 | 9.346025 | 3.511948 | 24.871710 | <0.00001 | 0.000025 | 10.98626 | 3.603866 | 33.491280 |
| ≥2 previous surgeries | 0.19911 | 0.193737 | 1.904468 | 0.720856 | 5.031513 | 0.95013 | 0.948494 | 1.049644 | 0.24133 | 4.565341 |
| Thyroglobulin >10 | 0.00525 | 0.011737 | 4.846018 | 1.420168 | 16.536032 | 0.00092 | 0.011400 | 13.569626 | 1.800102 | 102.291326 |
| Thyroglobulin >50 | 0.00013 | 0.000599 | 5.341095 | 2.051710 | 13.904170 | 0.00004 | 0.000445 | 7.456039 | 2.430113 | 22.876500 |
| Thyroglobulin >100 | 0.00004 | 0.000229 | 5.63063 | 2.245818 | 14.116890 | 0.00001 | 0.000193 | 7.282063 | 2.564559 | 20.677400 |
| Thyroid remnant | 0.86779 | 0.872798 | 1.073077 | 0.452544 | 2.544493 | 0.44648 | 0.464541 | 0.629342 | 0.181951 | 2.176803 |
| Distant metastases at time of Level VI/VII surgery | <0.00001 | 0.000009 | 6.072237 | 2.743882 | 13.437920 | <0.00001 | 0.000001 | 10.47164 | 4.031839 | 27.197729 |
| Extracapsular nodal extension | 0.01697 | 0.022995 | 2.865263 | 1.156295 | 7.100004 | 0.05163 | 0.063614 | 2.862623 | 0.942192 | 8.697391 |
| Largest node ≥1.5 cm | 0.00019 | 0.000872 | 1.078606 | 1.031609 | 1.127745 | 0.00622 | 0.012009 | 1.067466 | 1.014452 | 0.123251 |
| Largest node >3 cm | 0.00328 | 0.004963 | 1.139263 | 1.040217 | 1.247741 | 0.00216 | 0.003776 | 1.171961 | 1.052646 | 1.304798 |
| Soft-tissue invasion | 0.35794 | 0.340586 | 2.01552 | 0.476861 | 8.518878 | 0.13535 | 0.138817 | 3.036802 | 0.697685 | 13.218540 |
| Postoperative radiation therapy | <0.00001 | 0.000002 | 6.383369 | 2.997181 | 13.595240 | 0.00055 | 0.001186 | 4.662541 | 1.838545 | 11.823190 |
| Distant metastases during surveillance | <0.00001 | 0.000001 | 7.245101 | 3.265083 | 16.076630 | <0.00001 | 0.000003 | 18.994220 | 5.487747 | 65.742940 |
| Second primary malignancies | 0.57560 | 0.551182 | 1.549852 | 0.366869 | 6.547399 | 0.88468 | 0.874330 | 1.176784 | 0.156536 | 8.846667 |
Boldface indicates statistical significance
CI, confidence interval.