Table 3.

Boltzmann parameters of the activation curves for fast and slow gating analysis results from WT and six mutants

Mutant	Inheritance	V 1/2 (mV)		κ (mV)		Total N
		Fast	Slow	Fast	Slow
WT	Normal	−60 ± 10	−36 ± 17	20 ± 2	18 ± 2	10
S189C	A.D	5 ± 14	50 ± 5	52 ± 5	10 ± 1	13
P480S	A.D	−61 ± 5	−19 ± 15	28 ± 2	15 ± 2	6
M128I♦	A.R	0 ± 8	−100 ± 6	45 ± 8	49 ± 6	10
M373L♦	Sporadic	−52 ± 6	−126 ± 10	20 ± 2	18 ± 1	5
G523D♦	Sporadic	−91 ± 11	-	63 ± 7	-	10
M609K♦	Sporadic	−60 ± 1	-	18 ± 1	-	8

^♦indicates that the mutant showed reversed pattern of activation curve for slow gating.

^-indicates that no value was calculated to fit with Boltzmann distribution.