Figure 4.
Ability of CBD (2.5–10 mg·kg−1, i.p.) or morphine (2.5–10 mg·kg−1, i.p.) to produce place conditioning in female C57Bl/6 mice. Mice received vehicle or morphine (2.5–10 mg·kg−1, i.p.; 15 min pretreatment) or vehicle or CBD (2.5–10 mg·kg−1, i.p.; 30 min pretreatment) on alternate days for 30 min conditioning sessions for 6 successive days. One-way anovas revealed no significant effect of CBD treatment [F(3, 31) = 2.477, n.s.] and a significant effect of morphine treatment on time spent in the white compartment compared with saline vehicle control [F(3, 30) = 15.66, P < 0.0001]. X-axis: treatment. Y-axis: the time spent in the drug-paired (white) compartment on the treatment-free test day.