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Calculated median-effect plot parameters and DRI for drugs and drug combinations
| Median-effect plot parameters | DRI | ||||
|---|---|---|---|---|---|
| Cell line | Chemotherapy | Dm | m | r | 50% inhibition |
| 4T1 | CBD | 2.7 μM | 2.5 | 0.98 | |
| PAC | 35 μM | 1.8 | 0.86 | 2.0 | |
| CBD + PAC | 18 μM | 3.0 | 0.99 | ||
| LN 231 | CBD | 4.1 μM | 3.2 | 0.99 | |
| Pac | 51 μM | 0.3 | 0.92 | 15 | |
| CBD + PAC | 5.0 μM | 2 | 1.0 | ||
The median-effect dose (Dm), slope (m), linear correlation coefficient (r) and DRI (dose-reduction index) for drugs were calculated using Compusyn.
