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. 2014 Jan 13;171(3):646–662. doi: 10.1111/bph.12460

Figure 2.

Figure 2

Effects of TAS2R10 agonists on MCh- and 5HT-induced airway constriction. Phase-contrast images (scale bar = 100 μm) of an airway in a lung slice under resting conditions and treated with (A) 400 nM MCh or (E) 1 μM 5HT in the absence and presence of chloroquine (CQN). (B, C) The effects of (B) chloroquine and (C) quinine (QN) at a range of concentrations and 0.5% DMSO vehicle in airways constricted with 400 nM MCh. (F, G) The effects of (F) chloroquine and (G) quinine at a range of concentrations in airways constricted with 1 μM 5HT. Each line represents the mean and each point represents the mean ± SEM of the lumen area normalized to the initial size at t = 0 s (D, H). The concentration-dependent bronchodilation of chloroquine, quinine and denotonium (DEN) in airways constricted with (D) 400 nM MCh and (H) 1 μM 5HT. Each point represents the mean ± SEM. All experiments were performed on lung slices prepared from 3 to 4 mice. *P < 0.05, significantly different from the MCh or 5HT responses.