Figure 9.

Effects of chloroquine and quinine on SR Ca²⁺ levels. The effect of (A) chloroquine (CQN) and (C) quinine (QN) on Ca²⁺ release from the SR store SR induced by caffeine. Left panel shows control response in the absence of (A) chloroquine or (C) QN. Representative traces, expressed as intensity (F_t) normalized to the initial intensity at t = 0 s (F₀), measured from a 10 × 10 pixel ROI of a single ASM cell. (B, D) Summary of the maximum fluorescence intensity generated by caffeine alone or in the presence of (B) chloroquine (n = 16, 3 mice) or (D) quinine (n = 12, 3 mice). Each bar represents the mean ± SEM.