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Hypoxia increases competitive binding of agonist to TPα; effect of C-terminal amino acid substitution mutation. HEK293T cells transfected with (A) human wild-type TPα, or serine-to-alanine mutants (B) Ser324A, (C) Ser329A or (D) Ser331A, following 48 h of hypoxic or normoxic exposure, were incubated with a saturating concentration of [3H]-SQ29548, before antagonist displacement with serial concentrations of cold agonist U46619. Data are from three experiments.
