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. 2014 Jan 13;171(3):676–687. doi: 10.1111/bph.12487

Table 3.

Dose-response relationships of TP receptors and TP substitution mutants in normoxia or hypoxia

Receptor log EC50a in normoxia log EC50a in hypoxia
TPα wt −7.24 ± 0.10 −8.31 ± 0.09
Ser324A −8.42 ± 0.08 −8.35 ± 0.08
Ser329A −7.21 ± 0.09 −8.39 ± 0.15
Ser331A −6.44 ± 0.09 −6.34 ± 0.17
a

log EC50 = log molar concentration of agonist U46619 that produces 50% of maximal peak calcium mobilization response for TP receptors and TP substitution mutant receptors. Boldface values differ from normoxic wild type (P < 0.05).