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. 2014 Jan 13;171(3):735–745. doi: 10.1111/bph.12491

Figure 5.

Figure 5

GR suppresses hypoxia-mediated induction of COX-2 via effects of on CBP. (A) A549 cells were pretreated with dexamethasone (0.1 μM) and/or TSA (1 μM) for 1 h before treatment with hypoxia for 24 h and analysed by Western. (B) A549 cells were transfected with 0.5 μg of COX-2-Luc reporter plasmid and treated as indicated, and luciferase activity was assayed. (C) A549 cells were transfected with 0.5 μg of COX-2-Luc reporter plasmid with or without CBP expression plasmids, treated as indicated, and luciferase expression was determined. Values represent the means ± SD (n = 3). *P < 0.05. Dex, dexamethasone. All experiments were repeated at least three times.