Figure 2.

Energy intake is increased by CD feeding, but not reduced by drug treatment. A: Compared with CD-fed rats, energy intake is even further enhanced by telmisartan (T) during the last weeks of treatment, but remained unaffected by amlodipine (A) or telmisartan + amlodipine (T + A) treatment. The dotted line indicates the beginning of drug treatment. B: Cumulative energy intake related to body weight during treatment period. The filled bars represent the proportion fed with chow, the open bars the proportion with CD. C: Correlation between plasma leptin and energy intake before and after the drug treatment. Arrows indicate a shift to higher values, representing the data at the end of drug treatment. D: Energy intake during calorimetry. The gray bars indicate the dark periods. Means ± SEM, n = 11–12, *P < 0.05 versus C_CD.