Figure 4.
CD feeding induces leptin resistance, which is selectively alleviated by telmisartan. At the first day, leptin was injected at 0800, 1100, 1400 and 1700 h (100 μg·kg−1 s.c. each time) and at 2000 h. (200 μg·kg−1 s.c.). At the second day, rats were treated with leptin at 0800 and 1100 h (100 μg·kg−1 s.c.) and at 1400 h (200 μg·kgv−1 s.c.). The gray bars indicate the dark periods. A: The energy intake after exogenous leptin is increased in CD- (CCD) compared with chow-fed controls (Cchow), which indicates leptin resistance. B–D: Leptin sensitivity is partially restored by telmisartan (T), but not by amlodipine (A) and the combination telmisartan + amlodipine (T + A). E–H: RER during the leptin exposure was only diminished by telmisartan compared with CCD, but not by amlodipine and telmisartan +amlodipine. Means ± SEM, n = 11–12, *P < 0.05 versus CCD.