Table 3. Benzothiazoles Derivatives Synthesized and Evaluated as CK-1δ Inhibitors.

compd	X	Z	Y	R1	R2	R3	R4	%inh @10 μM (%)	CK-1δ IC50 (μM)
MR-3.15	NH	CO	CH2	H	H	Cl	H	>60	0.85 ± 0.10
9	O	CO	CH2	H	H	H	Cl	20
10	NH	CO		CF3	OMe	H	H	25
11	NH	CH2	CH2	CF3	OMe	H	H	25
12	NH	CO	CHPh	H	H	H	H	>60	1.96 ± 0.83
13	NH	CO	CHPh	OEt	H	H	H	>60	2.82 ± 0.43
14	NH	CO	CH2CH2	H	H	Cl	H	>60	3.58 ± 0.21
15	NH	CO	CH2CHPh	H	H	H	H	>60	2.50 ± 0.33
16	NH	CO	NH	CF3	H	H	OMe	>60	5.50 ± 0.11