Table 4. N-Benzothiazolyl-2-phenyl-acetamides Derivatives Synthesized and Evaluated as CK-1δ Inhibitors.

compd	R	R1	R2	R3	R4	R5	%inh @10 μM (%)	CK-1δ IC50 (μM)
MR-3.15	H	H	H	Cl	H	H	>60	0.85 ± 0.10
17	H	Me	H	Cl	H	H	>60	0.083 ± 0.003
18	Me	H	H	Cl	H	H	20
19	Cl	H	H	Cl	H	H	20
20	H	CF3	H	Cl	H	H	>60	0.023 ± 0.002
21	H	OMe	H	Cl	H	H	>60	0.53 ± 0.07
22	H	OCF3	H	Cl	H	H	>60	0.54 ± 0.02
23	H	OEt	H	Cl	H	H	>60	1.21 ± 0.09
24	H	CF3	Cl	H	H	H	>60	0.068 ± 0.007
25	H	OMe	Cl	H	H	H	>60	9.71 ± 0.99
26	H	OEt	Cl	H	H	H	>60	17.43 ± 1.21
27	H	CF3	H	H	Cl	H	>60	0.065 ± 0.003
28	H	OMe	H	H	Cl	H	>60	0.75 ± 0.09
29	H	OEt	H	H	Cl	H	>60	1.11 ± 0.29
30	H	Br	OMe	H	H	H	>60	0.26 ± 0.02
31	H	Cl	OMe	H	H	H	>60	0.32 ± 0.03
32	H	F	OMe	H	H	H	>60	1.17 ± 0.51
33	H	Me	OMe	H	H	H	>60	0.29 ± 0.03
34	H	CF3	OMe	H	H	H	>60	0.010 ± 0.001
35	H	OMe	OMe	H	H	H	>60	2.22 ± 0.30
36	H	OCF3	OMe	H	H	H	>60	0.62 ± 0.06
37	H	OEt	OMe	H	H	H	>60	5.76 ± 0.61
38	H	CF3	H	OMe	H	H	>60	0.042 ± 0.050
39	H	OMe	H	OMe	H	H	>60	0.42 ± 0.06
40	H	OEt	H	OMe	H	H	>60	0.99 ± 0.07
41	H	CF3	H	CF3	H	H	>60	0.087 ± 0.033
42	H	CF3	H	H	OMe	H	>60	0.033 ± 0.002
43	H	OMe	H	H	OMe	H	>60	0.57 ± 0.08
44	H	OEt	H	H	OMe	H	>60	1.09 ± 0.12
45	H	H	H	H	H	H	>60	0.33 ± 0.03
46	H	CF3	H	H	H	H	>60	0.047 ± 0.005
47	H	CF3	H	Cl	Cl	H	>60	0.056 ± 0.002
48	H	OMe	H	Cl	Cl	H	>60	1.24 ± 0.17
49	H	OEt	H	Cl	Cl	H	>60	3.43 ± 0.69
50	H	OCF3	H	Cl	Cl	H	>60	0.59 ± 0.04
51	H	CF3	OMe	H	H	OMe	>60	0.19 ± 0.05
52	H	OCF3	H	OMe	OMe	OMe	>60	0.079 ± 0.007
53	H	OMe	H	OMe	OMe	OMe	>60	1.12 ± 0.41
54	H	OEt	H	OMe	OMe	OMe	>60	1.43 ± 0.35
55	H	CF3	H	OMe	OMe	OMe	>60	0.015 ± 0.007