Table 1.
Differential pseudovirus neutralization responses informed by hierarchical clustering.
| Cluster | n | Median (IQR) serum neutralization titers against indicated HPV pseudovirusa |
|||||
|---|---|---|---|---|---|---|---|
| HPV16 | HPV31 | HPV33 | HPV35 | HPV52 | HPV58 | ||
| I | 13 | 74,295 (55,880–122,896) | 482 (195–665) | 54 (24–87) | 22 (10–68) | 21 (10–25) | 20 (10–32) |
| II | 5 | 20,556 (20,032–20,559) | 58 (51–98) | 23 (10–27) | 27 (25–49) | 10 (10–25) | 10 (10–10) |
| III | 7 | 9721 (5959–12,954) | 31 (27–33) | 10 (10–10) | 10 (10–10) | 10 (10–10) | 10 (10–10) |
| IV | 10 | 6953 (4366–11,584) | 10 (10–10) | 10 (10–10) | 10 (10–10) | 10 (10–18) | 10 (10–10) |
| V | 7 | 18,351 (17,026–25,055) | 45 (42–84) | 10 (10–21) | 10 (10–10) | 28 (25–35) | 10 (10–10) |
| VI | 8 | 13,302 (11,612–17,578) | 108 (57–166) | 30 (25–37) | 10 (10–10) | 10 (10–10) | 10 (10–10) |
| VII | 6 | 8275 (6386–11,407) | 87 (70–107) | 10 (10–10) | 10 (10–10) | 10 (10–10) | 10 (10–10) |
| VIII | 13 | 25,962 (21,195–40,113) | 152 (90–399) | 10 (10–26) | 10 (10–10) | 10 (10–10) | 10 (10–10) |
a
Median (IQR, interquartile range) neutralizing antibody titers of sera within indicated intuitive clusters against indicated HPV pseudoviruses.