Fig. 4.

Visualized network analysis. Based on information about signal transduction networks contained in the BKL database, key node search analyses for several gene sets have been performed. The obtained results have been combined and visualized. Highlighted (red) molecules have been upregulated as demonstrated by microarray data. Aurora A denotes aurora kinase A, aVb3 the vitronectin receptor, C/EBP the CCAAT-enhancer binding protein, COP1 the ring finger and WD repeat domain 2, C-Cbl the Cas-Br-M ectropic retroviral transforming sequence, ER estrogen receptor, Grb-2 growth factor receptor-bound protein, HIF-PH2 hypoxia-inducible factor prolyl hydroxylase 2, IRS-1 insulin receptor substrate 1, MEK1 the kinase MAP2K1, PAK p21 protein-activated kinase, TGF transforming growth factor, TrkA1 the neurotrophic tyrosine kinase receptor type 1. Further abbreviations are referred to in the article text. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)