Table 1.
Functional classification by canonical pathway mapping. The genes of the upregulated (↑) and downregulated (↓) sets were classified according to their biological processes and gene ontology (GO) IDs by GO annotation, using manually curated GO groups. In accordance, the same gene sets were compared to annotated Transpath pathways. Enolase 2 is symbolized as ENO2, platelet-type 6-phosphofructokinase as PFKP, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as PFKFB4, aldolase C as ALDOC, mannose-6-phosphate isomerase as MPI, phosphoglycerate kinase 1 as PGK1, liver-type 6-phosphofructokinase as PFKL, glucose-6-phosphate isomerase as GPI, triosephosphate isomerase as TPI, hexokinase as HK, glutamic pyruvate transaminase 2 as GPT2, pyruvate dehydrogenase kinase isoenzyme 1 as PDK1, fucosyltransferase 11 as FUT11, stanniocalcin 2 as STC2, pyruvate dehydrogenase kinase isozyme 3 as PDK3, Cas-Br-M ecotropic retroviral transforming sequence as CBL, cAMP responsive element binding protein 1 as CREB1 (CREB-A and CREB-B), growth factor receptor-bound protein 10 as GRB10, glycogen synthase as GYS1, insulin receptor as INSR, mitogen-activated protein kinase kinase 1 as MAP2K1 (=MEK1), mitogen-activated protein kinase kinase 7 as MAPK7 (=ERK5), neural precursor cell expressed developmentally downregulated 4-like as NEDD4L, and glutamate dehydrogenase as GLUD.
| Gene set | 1. GO ID//2. Pathway ID | 1. GO Term//2. Pathway term | Hits | p-Value |
|---|---|---|---|---|
| ↑ | GO:0001666 | Response to hypoxia | [34] | 6.74E−20 |
| ↑ | GO:0019318 | Hexose metabolic process | ALDOC, ENO2, FUT11, GP1, GPT2, GYS1, HKl, HK2, MPI, PDK1, PDK3, PFKFB4, PFKL, PFXP, PGK1, STC2, TPI1 | 2.28E−08 |
| ↑ | GO:0001568 | Blood vessel development | [27] | 4.07E−08 |
| ↓ | GO:0008152 | Metabolic process | [127] | 5.46E−05 |
| ↑ | CH000003595 | Glycolysis | PFKP, PFKL, ALDOC, GPI, HK2, HK1, MPI, PGK1, TPI1 | 1.65E−07 |
| ↑ | CH000003563 | Glucose → pyruvate | PFKL. PFKP, ALDOC, GP1, HK2, HK1, PGK1, TPI | 2.11E−O7 |
| ↑ | CH000000750 | Insulin pathway | CBL, CREB1, MAPK7, GRB10, GYS1. INSR, MAP2K1, NEDD4L | 3.71E−06 |
| ↓ | CH000003662 | L-glutamate → 2-oxoglutarate | GLUD1, GLUD2 | 8.95E−06 |