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Top panel residual bivalirudin effects on thrombin-mediated platelet aggregation. Platelet aggregation was measured in platelets pre-treated with varying concentrations of bivalirudin (0–10 μg).F ollowing pre-treatment, platelets were washed either once or twice and resuspended in platelet buffer. Maximal platelet aggregation was measured. Bottom panel comparison of basal levels of PAC-1 and P-selectin before and after treatment with bivalirudin (N = 57; NS)
