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. Author manuscript; available in PMC: 2014 Mar 28.
Published in final edited form as: J Med Chem. 2012 Oct 26;55(22):10160–10176. doi: 10.1021/jm3012728

Table 2.

Impact of the E185A and I228R Mutations on the Affinity of 13 for SaFtsZ at 25 °Ca

SaFtsZ Kd (μM)
wild-type 3.5 ± 0.5
E185A 38.3 ± 5.4
I228R 32.9 ± 6.2
a

Solution conditions were as described in the footnote to Table 1.