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Antibacterial Activities of 13–15 against E. coli
| MIC (μg/mL)
|
|||
|---|---|---|---|
| compound or control agent | ATCC BAA-201a (ESBL) | W4573 | N43b (acrA1) |
| 13 | 16.0 | 16.0 | 2.0 |
| 14 | 64.0 | 64.0 | 8.0 |
| 15 | >64.0 | >64.0 | 32.0 |
| ampicillin | >64.0 | 4.0 | 2.0 |
| amikacin | >64.0 | 2.0 | 1.0 |
ATCC BAA-201 is an extended spectrum β-lactamase (ESBL)-producing strain that expresses the TEM-3 lactamase.
N43 is an AcrAB efflux pump mutant strain of W4573.
