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. Author manuscript; available in PMC: 2014 Mar 28.
Published in final edited form as: J Med Chem. 2012 Oct 26;55(22):10160–10176. doi: 10.1021/jm3012728

Table 6.

Comparison of MIC and MBC Values for 13 in S. aureus and E. coli

compound or control agenta MIC (μg/mL) MBC (μg/mL) MBC/MIC
S. aureus 8325-4
13 1.0 1.0 1
vancomycin 0.5 1.0 2
erythromycin 0.125 32.0 256
E. coli W4573
13 16.0 16.0 1
neomycin 1.0 2.0 2
a

Vancomycin and neomycin are included as control bactericidal agents, while erythromycin is included as a control bacteriostatic agent.