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. 2014 Jan 16;6(2):301–312. doi: 10.1016/j.celrep.2013.12.033

Figure 3.

Figure 3

Behavioral Responses of Nav1.3, Nav1.8, and Nav1.9 Knockout Mice Reveal Critical Roles in Modality-Specific Responses to CCI-Induced Pain but Not Sympathetically Mediated SNT Pain

Behavioral von Frey and acetone responses of Nav1.3, Nav1.8, or Nav1.9 knockouts following CCI (A) and L5 SNT surgery (B). Nav1.3KO mice (orange squares, n = 6) show reduced CCI-induced cold allodynia (Aa) and mechanical allodynia (Ab) in comparison to littermate mice (white squares, n = 10). Nav1.8KO mice (light blue squares, n = 8) show diminished CCI-induced cold allodynia (Ac) but do develop mechanical allodynia (Ad) in comparison to littermate mice (white squares, n = 10). Nav1.9KO mice (turquoise squares, n = 8) show diminished CCI-induced cold allodynia (Ae) but do develop mechanical allodynia (Af) in comparison to littermate mice (white lines, n = 8). Nav1.3KO mice (orange squares, n = 10) develop both L5 SNT-induced cold (Ba) and mechanical allodynia (Bb) in comparison to littermate mice (white squares, n = 8). Nav1.8KO mice (light blue squares, n = 8) develop L5 SNT-induced cold (Bc) and mechanical allodynia (Bd) in comparison to littermate mice (white squares, n = 8). Nav1.9KO mice (turquoise squares, n = 10) develop L5 SNT-induced cold (Be) and mechanical allodynia (Bf) in comparison to littermate mice (white squares, n = 7). Data analyzed by two-way analysis of variance followed by the Bonferroni post hoc test. Results are presented as mean ± SEM. ∗∗p < 0.01 and ∗∗∗p < 0.001 (individual points).