Table 2.

Summary of Distinct Neuronal Subpopulations and Mechanisms Underlying Different Neuropathic Pain Models

VGSC	Deleted from	Chronic Constriction Injury		Spinal Nerve Transection		Oxaliplatin-Induced Pain
Cold Allodynia	Mechanical Allodynia	Cold Allodynia	Mechanical Allodynia	Cold Allodynia	Mechanical Allodynia
Nav1.3	CNS/PNS	attenuated	attenuated	normal	normal	normal	normal
Nav1.7	Nociceptors	lost	normal	normal	normal	normal	normal
Sensory neurons	lost	lost	normal	normal	normal	normal
Sympathetic and sensory neurons	lost	lost	lost	lost	normal	normal
Nav1.8	Nociceptors	attenuated	normal	normal	normal	normal	normal
Nav1.9	Nociceptors	attenuated	normal	normal	normal	normal	normal

VGSC, voltage-gated sodium channel; PNS, peripheral nervous system; CNS, central nervous system.