Table 1.
Studies included in the overall volumes meta-analyses.
| ID | Study | Year | N (F) | Age |
Volumes | ||
|---|---|---|---|---|---|---|---|
| Mean (SD) | Range | Category | |||||
| 1 | Abbs | 2011 | 48 (21) | 40.5a (10.8a) | – | 4 | Cb |
| 2 | Acer | 2008 | 53 (27) | – | 20–25 | 4 | Cbl |
| 3 | Allen | 1991 | 24 (12) | 9.1a (3.8a) | 2–15 | 6 | Cb |
| 122 (61) | 42a (13.8a) | 16–79 | 6 | ||||
| 4 | Allen | 2002 | 46 (23) | 32.4a (8.2a) | 22–49 | 4 | Cbl |
| 5 | Allen | 2003 | 46 (23) | 32.4a (8.2a) | 22–49 | 4 | Cb, GM, WM |
| 6 | Andreasen | 1994 | 90 (42) | 27.4 (10.3) | – | 4 | TBV, CSF, Cbl |
| 7 | Arango | 2008 | 66 (32) | 34.1a (7.3a) | 23–51 | 4 | ICV, TBV, CSF |
| 8 | Baibakov | 2010 | 60 (30) | 1a (0.08a) | 0–1 | 1 | TBV |
| 9 | Barnes | 2010 | 82 (34) | – | 33–35 | 4 | GM |
| 10 | Barrick | 2005 | 30 (15) | 28.8a | – | 4 | Cb, GM, WM |
| 11 | Barta | 2003 | 30 (15) | 39.1a (10.5a) | – | 4 | TBV |
| 12 | BDCG | 2012 | 325 (173) | 10.9a (3.8a) | 4–18 | 3 | TBV, GM, WM, Cbl |
| 13 | Beacher | 2012 | 30 (15) | 30a (8a) | – | 4 | WM |
| 14 | Blanton | 2004 | 46 (25) | 10.9a (2.9a) | 6–17 | 3 | ICV, GM, WM |
| 15 | Blatter | 1995 | 44 (20) | 22.3a (2.2a) | 16–25 | 4 | ICV, TBV, GM |
| 43 (24) | 30.8a (3.2a) | 26–35 | 4 | WM, CSF | |||
| 38 (22) | 40.9a (2.9a) | 36–45 | 4 | ||||
| 39 (24) | 50.6a (2.7a) | 46–55 | 4 | ||||
| 30 (15) | 60.2a (2.6a) | 56–65 | 4 | ||||
| 16 | Bloss | 2007 | 27 (14) | 3.7a (1.1a) | 1–5 | 2 | ICV, TBV, GM, WM, Cbl |
| 17 | Boes | 2008 | 117 (56) | 12.3a (2.8a) | 7–17 | 3 | GM |
| 18 | de Bruin | 2005 | 91 (44) | 49.7a (7.9a) | – | 4 | ICV, Cb, GM, WM, CSF, Cbl |
| 19 | Bryant | 1999 | 37 (18) | 33.8a (7.3a) | 21–45 | 4 | ICV |
| 20 | Buckner | 2004 | 168 (88) | 29.1a (11.7a) | – | 4 | ICV |
| 77 (57) | 76.8a (8.8a) | – | 5 | ||||
| 21 | Carne | 2006 | 97 (49) | 33.7 (13.6) | 15–69 | 6 | TBV, Cb, Cbl |
| 22 | Caviness | 1996 | 30 (15) | 9.2a | 7–11 | 3 | ICV, Cb, GM, WM, Cbl |
| 23 | Chen | 2007 | 411 (227) | 46.7a (1.4a) | 44–48 | 4 | ICV, GM, WM, CSF |
| 24 | Chen | 2012 | 27 (15) | 22.6a (1.8a) | – | 4 | TBV |
| 25 | Cheng | 2009 | 50 (25) | 27.1a (9.4a) | 19–50 | 4 | TBV, GM, WM |
| 26 | Choi | 2010 | 43 (21) | 24.5a (4a) | – | 4 | ICV |
| 27 | Chung | 2005 | 118 (60) | 23 (2.6) | – | 4 | Cbl |
| 100 (59) | 47.5 (3.7) | – | 4 | ||||
| 28 | Clayden | 2011 | 59 (34) | 11.5 (2.1) | 8–16 | 3 | ICV, WM |
| 29 | Coffey | 1998 | 330 (201) | 75 (5.1) | 66–96 | 5 | Cb |
| 30 | Collinson | 2003 | 30 (12) | 16.4 (1.7) | – | 3 | Cb |
| 31 | Courchesne | 2000 | 116 (37) | 21.4 (20) | 1–80 | 6 | ICV |
| 32 | Cowell | 2007 | S, 18 (8) | 35.3a (3.3a) | 20–49 | 4 | ICV |
| S, 16 (10) | 57.8a (2.5a) | 50–72 | 5 | ||||
| L, 19 (8) | 35.3a (3.1a) | 20–49 | 4 | ||||
| L, 15 (10) | 58.5a (2.5a) | 50–72 | 5 | ||||
| 33 | Crespo-Facorro | 2011 | 76 (31) | 28.1a (7.6a) | 15–51 | 4 | ICV, GM |
| 34 | De Bellis | 2001 | 118 (57) | 11.9a (2.4a) | 6–17 | 3 | ICV, Cb, GM, WM |
| 35 | DeCarli | 2005 | 1181 (233) | – | 34–54 | 4 | ICV |
| 517 (288) | – | 55–61 | 4 | ||||
| 546 (275) | – | 62–70 | 5 | ||||
| 487 (272) | – | 71–96 | 5 | ||||
| 36 | Duggal | 2005 | 30 (15) | 30a (9.5a) | – | 4 | ICV |
| 37 | Edland | 2002 | 184 (121) | 79a (6.5a) | – | 5 | ICV |
| 38 | Eliez | 2001 | 85 (64) | 10.6a (2.9a) | – | 3 | Cb, GM, WM, CSF |
| 40 | Fahim | 2012 | 38 (20) | 8.4a (0.1a) | – | 3 | GM, WM, CSF |
| 41 | Filipek | 1994 | 20 (10) | 27.2a (5.2a) | 17–37 | 4 | TBV, Cb, GM, WM, Cbl |
| 42 | Frederikse | 1999 | 30 (15) | 39.1a | 23–58 | 4 | TBV |
| 43 | Garcia-Falgueras | 2006 | 91 (51) | 20.1a (2.8a) | 18–33 | 4 | ICV, GM, WM, CSF |
| 44 | Ge | 2002 | 54 (22) | 46.8 (19.3) | 20–86 | 6 | ICV, GM, WM |
| 45 | Gilmore | 2007 | 74 (34) | 0.8a (0.03a) | 0.7–0.9 | 1 | ICV, Cbl |
| 46 | Goldstein | 2001 | 48 (21) | 39.8 (11.4a) | – | 4 | Cb, GM, WM |
| 47 | Good | 2001a | 465 (200) | 32a (12.2a) | 17–79 | 6 | GM, WM, CSF |
| 48 | Guo | 2008 | 158 (80) | 15 (4.7) | 7–22 | 6 | ICV, GM, WM |
| 49 | Gur | 1991 | 69 (35) | 42.9a (20.4a) | 18–80 | 6 | TBV, CSF |
| 50 | Gur | 1999 | 80 (40) | 26a (5.5a) | 18–45 | 4 | ICV, TBV, GM, WM, CSF |
| 51 | Gur | 2002 | 116 (59) | 26a (5.5a) | 18–49 | 4 | ICV, GM, WM, CSF |
| 52 | Hänggi | 2010 | 43 (25) | 22.3 (2.5) | 19–32 | 4 | ICV, GM, WM, CSF |
| 53 | Hogan | 2011 | 228 (107) | 68.7a (0.7a) | 68–69 | 5 | ICV |
| 54 | Hommer | 2001 | 39 (19) | 40.8a (7.7a) | – | 6 | ICV, GM, WM |
| 55 | Hoogendam | 2012 | 3962 (2156) | 60.1 (8.5) | >45 | 6 | ICV |
| 56 | Hutchinson | 2003 | 120 (60) | 25.1a (4.6a) | – | 4 | TBV, Cbl |
| 57 | Jenkins | 2000 | 52 (28) | 56.1 (12.1) | 36–85 | 6 | ICV |
| 58 | Knaus | 2004 | 24 (12) | 31.4 (8.9) | 21–53 | 4 | ICV |
| 59 | Koscik | 2009 | 76 (38) | 26.7a (7.2a) | 18–47 | 4 | Cb |
| 60 | Kruggel | 2006 | 290 (145) | 24.2a (2.8a) | 18–32 | 4 | ICV, TBV, GM, WM, CSF |
| 61 | Lai | – | 60 (30) | 27.9a (6.1a) | 18–49 | 4 | ICV, TBV, GM, WM, CSF |
| 62 | Lavretsky | 2004 | 41 (20) | 72.2 (7.3) | – | 5 | ICV |
| 63 | Lee | 2004 | 62 (28) | – | 18–77 | 6 | ICV, GM, WM |
| 64 | Lee | 2009a | 57 (29) | 24.4a (2.1a) | 20–28 | 4 | ICV, Cbl |
| 58 (26) | 67.8a (3.1a) | 62–74 | 5 | ||||
| 65 | Lee | 2009b | 68 (39) | 21.7 (2.3) | 20–29 | 4 | ICV |
| 66 | Lemaître | 2005 | 662 (331) | 69.5a (3a) | 63–75 | 5 | ICV, GM, WM, CSF |
| 67 | Lentini | 2012 | 86 (45) | 35.1a (7.1a) | 26–51 | 4 | ICV, TBV, GM, WM, CSF |
| 68 | Leonard | 2008 | 200 (100) | 21.6a | – | 4 | ICV, GM, WM, CSF, Cbl |
| 69 | Li | 2012 | 76 (38) | 43a (15.9a) | 19–70 | 6 | TBV, GM |
| 70 | Luders | 2002 | 100 (50) | 24.7a (4.4a) | – | 4 | ICV, GM, WM, CSF |
| 71 | Luders | 2003 | 59 (29) | 24.3a (5a) | – | 4 | ICV |
| 72 | Luders | 2005 | 60 (30) | 24.8a (4.5a) | – | 4 | ICV, GM, WM, CSF |
| 73 | Maller | 2006 | 150 (74) | 62.3a (1.4a) | 60–64 | 5 | TBV |
| 74 | Mann | 2011 | 70 (35) | 54.5a (20.3a) | 20–87 | 6 | Cb |
| 75 | Matsumae | 1996 | 12 (6) | – | 24–40 | 4 | ICV, TBV, |
| 15 (5) | – | 41–60 | 4 | CSF | |||
| 22 (12) | – | 61–80 | 5 | ||||
| 76 | Mitchell | 2003 | 100 (56) | 32.6 (12.3) | 14–68 | 6 | Cb |
| 77 | Mortamet | 2005 | 10 (5) | – | 20–29 | 4 | ICV, GM, |
| 10 (5) | – | 30–39 | 4 | WM, CSF | |||
| 10 (5) | – | 40–49 | 4 | ||||
| 10 (5) | – | 50–59 | 4 | ||||
| 10 (5) | – | 60–69 | 5 | ||||
| 78 | Narr | 2007 | 65 (35) | 28.2a (7.3a) | – | 4 | ICV, GM, WM, CSF |
| 79 | Neufang | 2009 | 46 (23) | 11.3a (2.2a) | 8–15 | 3 | TBV |
| 80 | Nopoulos | 1997 | 80 (40) | 28.1a (7.4a) | – | 4 | TBV, CSF |
| 81 | Nopoulos | 2000 | 84 (42) | 23.3a (3.3a) | 19–31 | 4 | ICV, Cb, CSF, Cbl |
| 82 | Nunnemann | 2009 | 133 (73) | – | 29–80 | 6 | ICV, GM |
| 83 | Passe | 1997 | 43 (30) | 53.7a (17.9a) | 24–82 | 6 | TBV, GM, WM |
| 84 | Paus | 2010 | 419 (215) | 15.3a (1.92a) | – | 3 | ICV, GM, WM |
| 85 | Peper | 2009 | 78 (41) | 11.9a (1.1a) | 10–14 | 3 | ICV, GM, WM, Cbl |
| 86 | Hulshoff Pol | 2006 | 15 (6) | 24.2a (7.3a) | 16–50 | 4 | ICV, TBV, GM, WM |
| 87 | Ponseti | 2007 | 49 (25) | 25.1a (3.3a) | – | 4 | GM, WM, CSF |
| 88 | Qiu | 2013 | 161 (74) | 0.03a (0.02a) | – | 1 | ICV |
| 89 | Rametti | 2011 | 38 (19) | 32.5a (7.2a) | – | 4 | ICV, GM, WM, CSF |
| 90 | Reig | 2011 | 94 (33) | 15.4 (1.4) | 9–19 | 3 | ICV, GM, WM, CSF |
| 91 | Reiss | 1996 | 85 (64) | 10.6a (2.9a) | 5–17 | 3 | ICV, GM, WM, CSF |
| 92 | Reiss | 2004 | 31 (17) | 8.5 (0.7) | 7–11 | 3 | GM, WM, CSF |
| 93 | Resnick | 2000 | 116 (48) | 70.4 (7.5) | 59–85 | 5 | TBV, GM, WM |
| 94 | Rhyu | 1999 | 20 (11) | – | 20–29 | 4 | Cbl |
| 19 (9) | – | 30–39 | 4 | ||||
| 23 (13) | – | 40–49 | 4 | ||||
| 20 (10) | – | 50–59 | 4 | ||||
| 23 (12) | – | 60–69 | 5 | ||||
| 19 (12) | – | 70–79 | 5 | ||||
| 95 | Riello | 2005 | 133 (95) | – | ≤60 | 4 | ICV, GM, |
| 96 (63) | – | >60 | 5 | WM | |||
| 96 | Rijpkema | 2012 | 1004 (591) | 22.8a (3.4a) | 18–36 | 4 | GM, WM |
| 97 | Sachdev | 2008 | 383 (172) | 62.7a (1.4a) | 60–64 | 5 | ICV |
| 98 | Salinas | 2012 | 108 (54) | 12.3a (2.9a) | 7–17 | 3 | Cb |
| 99 | Sandu | 2008 | 18 (10) | 13.8 (0.5) | – | 3 | ICV |
| 100 | Savic | 2011 | 48 (24) | 34a (6a) | 26–48 | 4 | ICV, TBV, GM, WM |
| 101 | Schlaepfer | 1995 | 60 (17) | 31.6a (7.9a) | – | 4 | ICV |
| 102 | Sgouros | 1999 | 33 (15) | 2.1a (1.6a) | 0–4 | 2 | ICV |
| 11 (3) | 8.1a (1.5a) | 5–9 | 3 | ICV | |||
| 24 (8) | 12.9a (1.5a) | 10–15 | 3 | ICV | |||
| 103 | Shan | 2005 | 13 (8) | 27.4a (4.9a) | – | 4 | TBV |
| 13 (8) | 69.8a (1.9a) | – | 5 | ||||
| 104 | Shin | 2005 | 30 (15) | 27.2a (6.3a) | – | 4 | ICV |
| 105 | Soloff | 2008 | 30 (19) | 25.6 (7.7) | – | 4 | ICV |
| 106 | Sowell | 2007 | 176 (86) | 32.4a (21.8a) | 7–87 | 6 | ICV, GM, WM, CSF |
| 107 | Sparks | 2002 | 26 (8) | 4 (0.5) | 3–4 | 2 | Cb, Cbl |
| 108 | Sullivan | 2001 | 92 (41) | 46.9a (15.1a) | 22–71 | 6 | ICV |
| 109 | Sullivan | 2004 | 143 (48) | 49.3a (16.9a) | 20–85 | 6 | ICV |
| 110 | Sullivan | 2005 | 128 (44) | – | 20–85 | 6 | ICV |
| 111 | Takahashi | 2004 | 61 (31) | 24.5 (5.5) | 18–38 | 4 | ICV |
| 112 | Takao | 2010 | 109 (58) | 26.3a (2.1a) | 21–29 | 4 | GM, WM |
| 113 | Tepest | 2010 | 29 (11) | 33 (9.1) | 20–55 | 4 | TBV |
| 114 | Uematsu | 2012 | 27 (9) | – | 0–2 | 1 | TBV |
| 34 (17) | – | 2–10 | 2 | ||||
| 48 (26) | – | 10–25 | 6 | ||||
| 115 | Wang | 2012 | 140 (70) | 20.9a (1.8a) | 18–26 | 4 | ICV, GM, WM, CSF |
| 116 | Whitwell | 2001 | 55 (31) | – | 23–83 | 6 | ICV |
| 117 | Wilke | 2007 | 67 (34) | 7.6a (1.2a) | – | 3 | GM, WM |
| 66 (34) | 11.1a (1a) | – | 3 | ||||
| 67 (34) | 15.6a (1.7a) | – | 3 | ||||
| 118 | Witte | 2010 | 34 (17) | 26.6 (5) | 21–47 | 4 | ICV, GM, WM, CSF |
| 119 | Wood | 2008a | 60 (30) | 28.9a (8.4a) | 18–50 | 4 | ICV, GM |
| 120 | Wood | 2008b | 74 (37) | 12.5a (2.9a) | 7–17 | 3 | ICV, Cb |
| 121 | Yamasue | 2008 | 155 (66) | 28.5a (4.2a) | 21–40 | 4 | ICV, GM, WM, CSF |
| 122 | Yang | 2008 | 57 (23) | 11.7 | 7–17 | 3 | ICV, GM, WM, CSF |
| 123 | Yoshii | 1988 | 58 (29) | 56.3 (17.5) | 21–81 | 6 | ICV |
| 124 | Ystad | 2009 | O, 84 (60) | 65.1 | 47–75 | 5 | ICV, Cb |
| B, 86 (60) | 59.3 | 46–77 | 5 | ||||
| 125 | Yurgelun-Todd | 2002 | 30 (20) | 14.7 (1.5) | 13–17 | 3 | ICV, GM, WM |
| 126 | Zhang | 2007 | 24 (12) | 27.7 (4.4) | 17–35 | 4 | WM |
| 12 (7) | 74.8 (2.6) | 72–80 | 5 | ||||
Abbreviations: B, Bergen; BDCG, brain development cooperative group; Cb, cerebrum (excluding CSF and Cbl); Cbl, cerebellum; CSF, cerebrospinal fluid; F, female; GM, grey matter; ICV, intracranial volume (including CSF); ID, identification number; L, Liverpool; N, number of participants; O, Oslo; S, Sheffield; SD, standard deviation; TBV, total brain volume (including Cbl but excluding CSF); WM, white matter.
a
Weighted mean and standard deviations.