. 2014 Feb;20(2):83–90. doi: 10.1016/j.molmed.2013.10.008

Table 1.

Genes associated with handedness related measures

Gene	Gene function	Study type^b	Cohort size	Cohort affection status	Refs
ACVR2B	Receptor for NODAL	GSEA of GWAS data	728	Individuals with dyslexia	[37]
GLI3	Ciliogenesis	GSEA of GWAS data	728	Individuals with dyslexia	[37]
GPC3	Heart/lung asymmetry	Strongest association in GWAS	2666	General population	[37]
LRRTM1^a	Neuronal development	Candidate gene	222	Dyslexic siblings	[32]
MNS1	Ciliogenesis	GSEA of GWAS data	728	Individuals with dyslexia	[37]
PCSK6	Cleaves NODAL into an active form	GW significant GWAS association	728	Individuals with dyslexia	[37,38]
PCSK6	Cleaves NODAL into an active form	Candidate gene	1113	General population	[49]
PKD2	Detects nodal flow	GSEA of GWAS data	728	Individuals with dyslexia	[37]
RFX3	Ciliogenesis	GSEA of GWAS data	728	Individuals with dyslexia	[37]

LRRTM1 is also associated with schizophrenia [32,33].

Abbreviations: GWAS, genome-wide association study; GW, genome wide; GSEA, gene set enrichment analysis.