Figure 4. Changes in serum ALT and AST activities after pharmacologic manipulation of catecholamine levels and adrenergic receptors in mice followed by exposure to 3 h of restraint.

Unrestrained animals were maintained in their cages. Mice were treated by vehicle control, reserpine (2 mg/kg), prazosin (1 mg/kg), yohimbine (2 mg/kg), betaxolol (20 mg/kg) or ICI 118,551 (5 mg/kg) before restraint. Drug-treated animals with 3 h of restraint or unrestraint were sacrificed at the same time points and serum ALT (A) and AST (B) activities were determined. Results are expressed as means±SD. There are 5 animals per group. * p<0.05, ** p<0.01 compared with control animals (untreated restraint animals); ^# p<0.05, ^## p<0.01compared with control animals (corresponding unrestrained animals).