. 2014 Mar 28;9(3):e91430. doi: 10.1371/journal.pone.0091430

Table 2. Labels used to refer to each cyclotide considered in this work and their activities against H. contortus and cells from the U-937GTB line.

Label	Proteins	H. contortus IC₅₀ (µM)	U-937GTB IC₅₀ (µM)	Ref
	Möbius
M1	kB1	2.48	6.9	[18], [20]
M2	[G1K]-kB1^a	0.5	-	[20]
M3	[L2K]-kB1^a	6.2	-	[20]
M4	[P3K]-kB1^a	>11.5	-	[20]
M5	[V4K]-kB1^a	11.1	-	[20]
M6	[G6K]-kB1^a	>11.5	-	[20]
M7	[E7K]-kB1^a	>11.5	-	[20]
M8	[T8K]-kB1^a	>11.5	-	[20]
M9	[V10K]-kB1^a	>11.5	-	[20]
M10	[G11K]-kB1^a	5.3	-	[20]
M11	[G12K]-kB1^a	>11.5	-	[20]
M12	[T13K]-kB1^a	2.8	-	[20]
M13	[N15K]-kB1^a	>11.5	-	[20]
M14	[T16K]-kB1^a	>11.5	-	[20]
M15	[P17K]-kB1^a	3.6	-	[20]
M16	[G18K]-kB1^a	1.1	-	[20]
M17	[T20K]-kB1^a	0.9	-	[20]
M18	[T20K, G1K]-kB1^a	0.4	-	[20]
M19	[T20K, S22K]-kB1^a	0.7	-	[20]
M20	[T20K, N29K]-kB1^a	0.4	-	[20]
M21	[T20K, N29K, G1K]-kB1^a	0.2	-	[20]
M22	[S22K]-kB1^a	2.3	-	[20]
M23	[W23K]-kB1^a	>11.5	-	[20]
M24	[V25K]-kB1^a	>11.5	-	[20]
M25	[T27K]-kB1^a	1.6	-	[20]
M26	[R28K]-kB1^a	3.9	-	[20]
M27	[N29K]-kB1^a	0.4	-	[20]
M28	kB2	1.59	2.6	[18], [51]
M29	kB6	0.87	-	[51]
M30	kB7	6.29	29	[18], [51]
M31	kB13	-	3.8	[18]
M32	cyH3	0.85	-	[51]
M33	cyO14	0.41	-	[51]
M34	cyO15	0.38	-	[51]
M35	cyO16	0.27	-	[51]
M36	cyO24	1.74	-	[51]
M37	vaby A	-	7.6	[47]
M38	vaby D	-	2.8	[47]
M39	varv A	1.13	8.2	[18], [51]
M40	[Cdr]-varv A	-	9.1	[18]
M41	[Cdr, Mee]-varv A	-	46	[18]
M42	[Mee]-varv A	-	34	[18]
M43	varv E	0.9	4	[49], [51]
M44	varv F	-	7.1	[13]
M45	vibi D	-	>30	[49]
	Bracelet
B1	circulin A	-	-	-
B2	circulin B	-	-	-
B3	cyO1	2.82	-	[51]
B4	cyO2	0.12	1.03	[18], [51]
B5	[Cdr]-cyO2	-	0.95	[22]
B6	[Cdr, Ack]-cyO2	-	5.1	[22]
B7	[Mee]-cyO2	0.76	36	[22], [51]
B8	[Ack]-cyO2	2.3	2.3	[22], [51]
B9	[Kyw]-cyO2	-	5.2	[18]
B10	cyO3	0.21	-	[51]
B11	cyO8	0.24	-	[51]
B12	cyO13	0.21	-	[51]
B13	cyO19	-	0.52	[18]
B14	cyY4	2.01	-	[51]
B15	cyY5	2.28	-	[51]
B16	psyle E	-	0.76	[48]
B17	vhl-1	2.06	-	[51]
B18	vibi E	-	3.2	[49]
B19	vibi G	-	0.96	[49]
B20	vibi H	-	1.6	[49]
B21	vitri A	-	0.6	[50]
B22	vodo O	-	3.2	[18]
	Hybrid
H1	[W23K, P24N, V25K]-kB1^a	-	-	-
H2	[P24K]-kB1^a	-	-	[20]
H3	[P24D, V25K]-kB1^a	-	-	-
H4	kB8	-	18	[18]
H5	psyle A	-	2	[48]
H6	tricyclon A	-	-	-
	Linear
L1	psyle C	-	3.5	[48]
L2	violacin A	-	-	-

The first residue in the sequence of kalata B1 is defined relative to the C-terminal amino acid involved in the biosynthetic ligation in loop 6. (See Figure 3).