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. 2014 Mar 28;9(3):e93171. doi: 10.1371/journal.pone.0093171

Table 1. Steps in the extended meta-analysis procedure to base nutrient recommendations on intake and health-related measurements.

Step Description Ref
1 Select valid studies on intake, status, and their relation; 5
both RCTs and observational this paper
2 Transform summary statistics for use to estimate parameters of the bivariate log-normal model 24
3 Perform (meta-)analysis to derive regression coefficients, separately for RCTs (brct) and observational IS studies (bobs) 5
4 Depending on assumptions and data checks, estimate the bivariate lognormal model parameters ANI, ANS, SDNI, SDNS and Inline graphic this paper
5 Based on an external health-related cut-off value Inline graphic derive estimates of ANR (EAR), INL (RDA), PNL this paper