Table 2. Models for estimation of the regression coefficient 
in 
.
| Model | Estimate of 
|
Assumption |
| A (RCT-based) | Meta-analysis of RCT Intake-Status data | Linear dose response in |
|
RCTs (on the ln-ln scale) | |
| B (obs-based) | Meta-analysis of observational Intake-Status data + de-attenuation | No intake-related bias, |
|
|
|
| C (CVNR 20%) | Observed Intake and Status variation + de-attenuation | Traditional value for |
|
variation in requirements, CVNR = 20% | |
| D (max slope) | Observed Intake and Status variation + minimal de-attenuation | No variation in |
|
requirements |