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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biol Psychiatry. 2013 Sep 28;76(3):223–230. doi: 10.1016/j.biopsych.2013.09.020

Figure 3.

Figure 3

Rats that underwent the CMS procedure were slower in gaining body weight and developed anxiety-like behavior, and there was a significant decrease in VTA DA neuron population activity. (A) CMS rats (n = 14) were significantly slower in gaining body weight compared to controls (CON; n = 14) (p < 0.05), and (B) developed anxiety-like behavior with less total time spent in the open arms (left) and fewer entries into the open arms (right) on the elevated plus maze (*, p < 0.05). (C) DA neuron population activity in CMS rats (n = 14, 80 neurons) was significantly lower than CON rats (n = 13, 134 neurons) (*, p < 0.05), with no significant differences in (D) mean firing rates or (E) bursting activity.