Table 2.

Odds of rapid eGFR_cys decline by BMI category

Model	BMI 25.0–29.9 (203/1713 [11.5%])		BMI 30.0–39.9 (153/1078 [14.2%])		BMI≥40.0 (34/208 [16.3%])
	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value
Unadjusted	1.53 (1.24–1.89)	<0.001	1.98 (1.57–2.49)	<0.001	2.36 (1.57–3.56)	<0.001
Adjusted MV modelb	1.50 (1.21–1.87)	<0.001	2.01 (1.57–2.87)	<0.001	2.57 (1.67–3.94)	<0.001
MV model + BMI change	1.49 (1.19–1.87)	<0.001	2.00 (1.56–2.58)	<0.001	2.74 (1.79–4.19)	<0.001
MV model + incident diabetes	1.51 (1.21–1.88)	<0.001	2.05 (1.60–2.64)	<0.001	2.65 (1.71–4.11)	<0.001
MV model + repeated systolic and diastolic BP measurements	1.44 (1.15–1.79)	0.001	1.85 (1.44–2.37)	<0.001	2.33 (1.58–3.54)	<0.001
MV model + repeated CRP measures	1.48 (1.17–1.86)	0.001	1.96 (1.48–2.59)	<0.001	2.46 (1.52–4.00)	<0.001
MV model + repeated albuminuria measures	1.56 (1.25–1.96)	<0.001	2.02 (1.57–2.61)	<0.001	2.36 (1.51–3.70)	<0.001
Fully adjusted (includes confounders + all potential mediatorsc)	1.50 (1.18–1.91)	0.001	1.95 (1.45–2.61)	<0.001	2.27 (1.36–3.78)	0.002

Note: Rapid eGFRcys decline defined as >3% decline per year. BMI expressed in kg/m²; column headings also give n/N [%], which corresponds to number of events per number of 5-year person-intervals, with the corresponding percentage. Reference group is BMI of 18.5–24.9 kg/m2 (179/2263 [7.9%]).

BMI, body mass index; BP, blood pressure; CRP, C-reactive protein; eGFR_cys, serum cystatin C–based estimated glomerular filtration rate; MV multivariate; OR odds ratio; CI. confidence interval

^bAdjusted for potential confounding by age, race, sex, hyperlipidemia, smoking status, and physical activity

^cPotential mediators include incident diabetes, interim systolic and diastolic BP measurements, repeated CRP, and repeated albuminuria measures